Pengepungan Nisibis terjadi saat Sasaniyah di bawah kepemimpinan Shah Shapur I mengepung kota Romawi Nisibis pada 252. Peristiwa tersebut menandai permulaan invasi kedua kekaisaran Romawi oleh Shapur I.
- ^ A Journey to Palmyra: Collected Essays to Remember Delbert R. Hillers "Sometime in the middle of the century, Shapur took possession of Armenia and invaded Roman Mesopotamia. Nisibis and Charrae fell into his hands"
- ^ Empress Zenobia: Palmyra's Rebel Queen "Shapur also claimed that he had devastated Syria and captured thirty-seven cities with their surrounding territories. He may have captured Nisibis, and destroyed Antioch."